Rózsa Balázs, M.D., Ph.D.
Balázs Rózsa, M.D., Ph.D.
Igazgató, BrainVisionCenter Nonprofit Kft.; csoportvezető, HUN-REN Kísérleti Orvostudományi Kutatóintézet; laboratóriumvezető, PPKE ITK; alapító és tudományos igazgató, Femtonics Kft.
Director, BrainVisionCenter Nonprofit Ltd.; Group Leader, HUN-REN Institute of Experimental Medicine; Head of Laboratory, PPCU FITB; Founder and Scientific Director, Femtonics Ltd.
Bemutatkozás
Dr. Rózsa Balázs orvos, fizikus és idegtudós, a BrainVisionCenter Nonprofit Kft. igazgatója, a HUN-REN Kísérleti Orvostudományi Kutatóintézet 3D Funkcionális Hálózati és Dendritikus Képalkotó Laboratóriumának vezetője, valamint a PPKE Információs Technológiai és Bionikai Karának laboratóriumvezetője. Orvosi diplomáját summa cum laude minősítéssel szerezte a Semmelweis Egyetemen, majd fizikusi és biofizikai képzettséget, illetve idegtudományi PhD-fokozatot szerzett. Munkája az idegrendszer nagysebességű, háromdimenziós vizsgálatára alkalmas képalkotó és fotostimulációs módszerek fejlesztését kapcsolja össze az alapkutatási és transzlációs idegtudománnyal. 2003-ban az elsők között fejlesztett robusztus, valós idejű 3D akusztooptikai szkenneralapú lézerpásztázó kétfoton-mikroszkópokat, amelyek a terület meghatározó technológiái közé tartoznak. Kutatásai a dendritikus számítás, a neuronhálózati aktivitás, a sejtszerelvények működése és a viselkedés közbeni vizuális tanulás kérdéseit vizsgálják. Technológiai fejlesztései lehetővé teszik nagy 3D térfogatok gyors mérését, idegsejtek szelektív aktiválását és komplex hálózati folyamatok valós idejű elemzését. A BrainVisionCenterben neurofotónikus eszközök és agyi interfészek fejlesztésén dolgozik, különös tekintettel a látáshelyreállítás és más központi idegrendszeri betegségek jövőbeli terápiás lehetőségeire. Tudományos eredményei magas hatású folyóiratokban, többek között a Science, Nature, Nature Methods, Nature Neuroscience, Neuron, Nature Communications, Cell és eLife hasábjain jelentek meg. Innovátori profilját a Femtonics Kft. alapító és tudományos igazgatói szerepe, valamint 50 megadott nemzetközi szabadalom és további szabadalmi bejelentések is erősítik.
Fő kutatási területek
- Idegtudomány, neurobiológia és rendszeridegtudomány
- Kétfoton-mikroszkópia, 3D akusztooptikai lézerpásztázó képalkotás és neurofotónika
- 3D funkcionális hálózati és dendritikus képalkotás in vivo és in vitro modellekben
- Dendritikus számítás, dendritikus integráció és sejtszerelvény-aktivitás
- Neuronális populációk kódolása, vizuális tanulás és viselkedés közbeni hálózati dinamika
- Fotostimulációs és kétfoton-uncaging technológiák
- Agy–gép interfészek, neurofotónikus eszközök és látáshelyreállítás
- Humán diagnosztikai és terápiás eszközök fejlesztése központi idegrendszeri betegségekhez
Jelenlegi pozíciók és szakmai profil
- 2022–: igazgató, BrainVisionCenter Nonprofit Kft., Budapest.
- 2016–: csoportvezető, 3D Funkcionális Hálózati és Dendritikus Képalkotó Laboratórium, Kísérleti Orvostudományi Kutatóintézet, Magyar Kutatási Hálózat / HUN-REN, Budapest.
- 2010–: vezető, Two-photon Imaging Center, Kísérleti Orvostudományi Kutatóintézet.
- 2010–: laboratóriumvezető, Információs Technológiai és Bionikai Kar, Pázmány Péter Katolikus Egyetem.
- 2005–: alapító és tudományos igazgató, Femtonics Kft., Budapest.
Szervezeti kapcsolódások, tagságok és szakmai együttműködések
- Szakmai azonosítók és profilok: ORCID: 0000-0003-1427-7003; ResearcherID: C-6306-2015; MTMT publikációs profil.
- Intézményi kapcsolódások: BrainVisionCenter Nonprofit Kft.; HUN-REN Kísérleti Orvostudományi Kutatóintézet; Two-photon Imaging Center; Pázmány Péter Katolikus Egyetem Információs Technológiai és Bionikai Kar; Femtonics Kft.
- Hazai szakmai együttműködések: PPKE; Semmelweis Egyetem; Budapesti Műszaki és Gazdaságtudományi Egyetem; Szegedi Tudományegyetem; Nemzeti Klinikai Idegtudományi Intézet; HUN-REN KOKI.
- Nemzetközi szakmai együttműködések: Institute of Molecular and Clinical Ophthalmology Basel / IOB; Columbia University; Medical University of Vienna; INSERM Marseille; Max Delbrück Center, Berlin; Max Planck Institute Martinsried; Cold Spring Harbor Laboratory; Ludwig-Maximilians-Universität München; Collège de France; University of Basel; Yale School of Medicine; Medical University of South Carolina; University of Pavia; University of Luxembourg; Radboud University; McGill University; Institute of Experimental Medicine, Prague; Institute of Molecular Biology, Taipei; Uniklinikum Jena; University of Regensburg; Institute of Neuroscience Shanghai, Chinese Academy of Sciences.
- Webes szakmai oldalak: brainvisioncenter.com; twophotonimaging.eu; femtonics.eu.
Szakmai szerepek és megbízatások
- Posztdoktori kutatók, PhD-hallgatók és MSc-hallgatók témavezetése; a szakmai utánpótlás képzésében 6 posztdoktor, 6 PhD-hallgató és 4 MSc-hallgató vezetése.
- ERC Consolidator Grant, VISONby3DSTIM (2016–2021): principal investigator.
- 3x3D Imaging FP7 projekt (2013–2016): principal investigator és koordinátor.
- H2020 projektek: AMPLITUDE, VISGEN és NEURAM kedvezményezett/közreműködő szerepekben.
- Nemzetközi és hazai kutatási projektek vezetése, illetve szakmai közreműködés svájci–magyar, francia–magyar, FP7, H2020, NKP, NVKP, GINOP, KFI és egyéb kutatás-fejlesztési programokban.
- Meghívott előadó és kurzusvezető nemzetközi egyetemeken, nyári iskolákban és konferenciákon, többek között Oxford, Shanghai ION, IBRO Summer School, MIT, UCL, Stanford University, Columbia University, Boston University, EPFL, FENS Forum, Gordon Research Conference, Photonics West és International Conference on BioMedical Photonics eseményeken.
- BrainVisionCenter kutatási és kompetenciaközpont fejlesztése neurofotónikus eszközök, agyi interfészek és látáshelyreállításhoz kapcsolódó technológiák területén.
- Femtonics Kft. alapító és tudományos igazgató; neurobiológiai képalkotó technológiák fejlesztése és hasznosítása.
Díjak és elismerések
- Gábor Dénes-díj (2024).
- Nemzeti Innovációs Díj (2023).
- Jedlik Ányos-díj – kiemelkedő sikeres feltalálói munka (2022).
- Az év legjobb PhD-témavezetője, Semmelweis Egyetem (2020).
- Nemzeti Innovációs Díj – „from basic research to market”, NKFIH (2020).
- Ernst & Young Entrepreneur Of The Year – Lifestyle of the Future (2017).
- ERC Consolidator Grant, VISONby3DSTIM (682426) (2016).
- Ernst & Young Entrepreneur Of The Year (2014).
- Magyary Zoltán professzori ösztöndíj (2013).
- Nemzeti Innovációs Díj (2012).
- PNAS-publikáció tudományos kiemelése: Scientific Highlight of the Year, FENS (2008).
- Junior Prima Primissima Díj (2007).
Válogatott publikációk
- Gonzalez KC; Terada S; Noguchi A; Zakka GN; O'Toole C; Bilbao G; Reynolds L; Jász A; Kertész B; Szadai Z; Shen A; St-Pierre F; Polleux F; Losonczy A; Rózsa B. (2026). Movement-stabilized three-dimensional optical recordings of membrane potential changes and calcium dynamics in hippocampal CA1 dendrites. Neuron.
- Judák L.; Dobos G.; Ócsai K.; Takács I.; Báthory E.; Chiovini B.; Szadai Z.; Maák P.; Szepesi Á.; Roska B.; Szalay G.; Rózsa B. (2024). Competition of cortical clusters during on-demand visual learning in immersive virtual reality. Nature Methods / Research Square preprint.
- Judák L.; Chiovini B.; Juhász G.; Pálfi D.; Mezriczky Z.; Szadai Z.; Katona G.; Szmola B.; Ócsai K.; Martinecz B.; Mihály A.; Dénes Á.; Kerekes B.; Szepesi Á.; Szalay G.; Ulbert I.; Mucsi Z.; Roska B.; Rózsa B. (2022). Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo. Nature Communications.
- Szalay G.; Judák L.; Katona G.; Ócsai K.; Juhász G.; Veress M.; Szadai Z.; Fehér A.; Tompa T.; Chiovini B.; Maák P.; Rózsa B. (2016). Fast 3D Imaging of Spine, Dendritic, and Neuronal Assemblies in Behaving Animals. Neuron.
- Chiovini B.; Turi GF.; Katona G.; Kaszás A.; Pálfi D.; Maák P.; Szalay G.; Szabó MF.; Szabó G.; Szadai Z.; Káli S.; Rózsa B. (2014). Dendritic spikes induce ripples in parvalbumin interneurons during hippocampal sharp waves. Neuron.
- Katona G.; Szalay G.; Maák P.; Kaszás A.; Veress M.; Hillier D.; Chiovini B.; Vizi ES.; Roska B.; Rózsa B. (2012). Fast two-photon in vivo imaging with three-dimensional random-access scanning in large tissue volumes. Nature Methods.
- Szalay G.; Martinecz B.; Lénárt N.; Környei Z.; Orsolits B.; Judák L.; Császár E.; Fekete R.; West BL.; Katona G.; Rózsa B.; Dénes Á. (2016). Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke. Nature Communications.
- Szadai Z.; Pi HJ.; Chevy Q.; Ócsai K.; Albeanu DF.; Chiovini B.; Szalay G.; Katona G.; Kepecs A.; Rózsa B. (2022). Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment. eLife.
- Munz M.; Bharioke A.; Kosche G.; Moreno-Juan V.; Brignall A.; Rodrigues TM.; Graff-Meyer A.; Ulmer T.; Haeuselmann S.; Pavlinic D.; Ledergerber N.; Gross-Scherf B.; Rózsa B.; Krol J.; Picelli S.; Cowan CS.; Roska B. (2023). Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex. Cell.
- Geiller T.; Sadeh S.; Rolotti SV.; Blockus H.; Vancura B.; Negrean A.; Murray AJ.; Rózsa B.; Polleux F.; Clopath C.; Losonczy A. (2022). Local circuit amplification of spatial selectivity in the hippocampus. Nature.
- Wertz A.; Trenholm S.; Yonehara K.; Hillier D.; Raics Z.; Leinweber M.; Szalay G.; Ghanem A.; Keller G.; Rózsa B.; Conzelmann KK.; Roska B. (2015). Single-cell-initiated monosynaptic tracing reveals layer-specific cortical network modules. Science.
Szabadalmak és szabadalmi bejelentések
Rózsa Balázs 50 megadott nemzetközi szabadalommal és további benyújtott szabadalmi bejelentésekkel rendelkezik. A linkelhető szabadalmi azonosítók Google Patents oldalra mutatnak.
Megadott szabadalmak
- EP2146234 – Laser scanning microscope (2008.12.31). E. S. Vizi, G. Katona, B. Rózsa
- US2011279893 – Laser scanning microscope (2011.07.27). E. S. Vizi, G. Katona, B. Rózsa
- US20140055852 – Laser scanning microscope (2013.11.15). E. S. Vizi, G. Katona, B. Rózsa
- US2011211254 – Laser scanning microscope for scanning along a 3D trajectory (2011.01.13). B. Rózsa et al.
- EP2307921 – Laser scanning microscope / 3D trajectory scanning family (2009.07.14). B. Rózsa et al.
- US2012044569 – Focusing system comprising acousto-optic deflectors for focusing an electromagnetic beam (2009.12.30). P. Maák, B. Rózsa, G. Katona, E. S. Vizi, M. Veress, A. Csákány, G. Szalay
- CA2748525 – Focusing system comprising acousto-optic deflectors for focusing an electromagnetic beam (2009.12.30). P. Maák, B. Rózsa, G. Katona, E. S. Vizi, M. Veress, A. Csákány, G. Szalay
- CN102334065 – Focusing system comprising acousto-optic deflectors for focusing an electromagnetic beam (2009.12.30). P. Maák, B. Rózsa, G. Katona, E. S. Vizi, M. Veress, A. Csákány, G. Szalay
- EP2399162 – Focusing system comprising acousto-optic deflectors for focusing an electromagnetic beam (2009.12.30). P. Maák, B. Rózsa, G. Katona, E. S. Vizi, M. Veress, A. Csákány, G. Szalay
- EP2187252 – Method and measuring system for scanning multiple regions of interest (2008.12.31). B. Rózsa et al.
- US2011279667 – Method and measuring system for scanning multiple regions of interest (2009.11.17). B. Rózsa et al.
- WO2013098568 – Compensator system and method for compensating angular dispersion (2012.01.05). B. Rózsa et al.
- CA2861716 – Compensator system and method for compensating angular dispersion (2012.01.05). B. Rózsa et al.
- CN104115062 – Compensator system and method for compensating angular dispersion (2012.01.05). B. Rózsa et al.
- EP2798401 – Compensator system and method for compensating angular dispersion (2012.01.05). B. Rózsa et al.
- 6286/DELNP/2014 – Compensator system and method for compensating angular dispersion (2012.01.05). B. Rózsa et al.
- 2014-549539 – Compensator system and method for compensating angular dispersion (2012.01.05). B. Rózsa et al.
- US20150029578A1 – Compensator system and method for compensating angular dispersion (2012.01.05). B. Rózsa et al.
- WO2013102771 – Method for scanning along a continuous scanning trajectory with a scanner system (2012.01.05). B. Rózsa et al.
- CA2861708 – Method for scanning along a continuous scanning trajectory with a scanner system (2012.01.05). B. Rózsa et al.
- CN104115061 – Method for scanning along a continuous scanning trajectory with a scanner system (2012.01.05). B. Rózsa et al.
- EP2800998 – Method for scanning along a continuous scanning trajectory with a scanner system (2012.01.05). B. Rózsa et al.
- 6294/DELNP/2014 – Method for scanning along a continuous scanning trajectory with a scanner system (2012.01.05). B. Rózsa, G. Katona, M. Veress, P. Maák, G. Szalay, A. Kaszás, B. Chiovini, P. Mátyás
- JP2014550762 – Method for scanning along a continuous scanning trajectory with a scanner system (2012.01.05). B. Rózsa, G. Katona, M. Veress, P. Maák, G. Szalay, A. Kaszás, B. Chiovini, P. Mátyás
- 14/368,932 – Scanning trajectory / scanner system patent family application (2012.01.05). B. Rózsa et al.
- WO2013098567 – Methods for measuring a 3-dimensional sample via measuring device comprising a laser scanning microscope and such measuring device (2012.01.05). B. Rózsa et al.
- CA2861721 – Methods for measuring a 3-dimensional sample via measuring device comprising a laser scanning microscope (2012.01.05). B. Rózsa, G. Katona, F. Csikor, P. Maák
- CN104137030 – Methods for measuring a 3-dimensional sample via measuring device comprising a laser scanning microscope (2012.01.05). B. Rózsa, G. Katona, F. Csikor, P. Maák
- EP2798443 – Methods for measuring a 3-dimensional sample via measuring device comprising a laser scanning microscope (2012.01.05). B. Rózsa, G. Katona, F. Csikor, P. Maák
- 6292/DELNP/2014 – Methods for measuring a 3-dimensional sample via measuring device comprising a laser scanning microscope (2012.01.05). B. Rózsa et al.
- JP2014549538 – Methods for measuring a 3-dimensional sample via measuring device comprising a laser scanning microscope (2012.01.05). B. Rózsa et al.
- US20150032414A1 – Methods for measuring a 3-dimensional sample via measuring device comprising a laser scanning microscope (2012.01.05). B. Rózsa et al.
- CN104011020 – Use of photocleavable compounds (2012.10.03). I. B. Rózsa et al.
- HU1200574 – Use of photochemically cleavable compounds (2012.10.03). B. Rózsa et al.
- EP3304184 – Layered structured acousto-optical deflector and method for optical beam deflection with deflector (2016.05.31). B. Rózsa et al.
- ZL201680040531 – Layered structured acousto-optical deflector and method for optical beam deflection (2016.05.31). B. Rózsa et al.
- E051482 – Layered structured acousto-optical deflector and method for optical beam deflection (2016.05.31). B. Rózsa et al.
- JP6866309 – Layered structured acousto-optical deflector and method for optical beam deflection (2016.05.31). B. Rózsa et al.
- US10613414 – Layered structured acousto-optical deflector and method for optical beam deflection (2016.05.31). B. Rózsa et al.
- ZL201780064861.8 – Method for scanning along a 3-dimensional line and for scanning a region of interest by scanning a plurality of 3-dimensional lines (2017.08.31). B. Rózsa et al.
- US11156819 – Method for scanning along a 3-dimensional line and for scanning a region of interest (2017.08.31). B. Rózsa et al.
- EP3507643 – Method for scanning along a 3-dimensional line and for scanning a region of interest (2017.08.31). B. Rózsa et al.
- E064140 – Method for scanning along a 3-dimensional line and for scanning a region of interest (2017.08.31). B. Rózsa et al.
- JP7226316 – Method for scanning along a 3-dimensional line and for scanning a region of interest (2017.08.31). B. Rózsa et al.
- JP7418715 – Method for scanning along a 3-dimensional line and for scanning a region of interest (2017.08.31). B. Rózsa et al.
- IN502445 – Method of scanning an optical beam using an acousto-optic deflector driven by chirped acoustic signals (2019.08.14). B. Rózsa et al.
- JP7444161 – Method of scanning an optical beam using an acousto-optic deflector driven by chirped acoustic signals (2019.08.14). B. Rózsa et al.
- US11927873 – Method of scanning an optical beam using an acousto-optic deflector driven by chirped acoustic signals (2019.08.14). B. Rózsa et al.
- EP3996498 – Virtual reality simulator and method for small laboratory animals (2020.07.09). B. Rózsa et al.
- 231390 – Modular respiratory machine (2023.03.23). B. Rózsa et al.
Benyújtott szabadalmi bejelentések
- P2300026; PCT/HU2023/050092 – Method for scanning an area with a multi-photon laser scanning microscope and such multi-photon laser scanning microscope (2022.12.22). B. Rózsa et al.
- P2200444; PCT/HU2023/050045 – Mobile laser scanning microscope and beam stabilizer for laser scanning microscope (2023.07.06). B. Rózsa et al.
- P2400333 – Microscope system with an optical arm and an optical arm for the examination of freely moving experimental animals (2024.06.25). B. Rózsa et al.
- P2400332 – Movement-stabilized Three-dimensional Two-photon Imaging (2024.06.25). B. Rózsa et al.
- P2300367 – Permanently charged fluorescent derivatization agents developed for glycomic application (2023.10.26). B. Rózsa et al.
- P2300414 – Pyruvate-based fluorescent markers for DNA detection (2023.11.27). B. Rózsa et al.
Introduction
Dr Balázs Rózsa is a physician, physicist and neuroscientist. He is Director of BrainVisionCenter Nonprofit Ltd., Group Leader of the Laboratory of 3D Functional Network and Dendritic Imaging at the HUN-REN Institute of Experimental Medicine, and Head of Laboratory at the Faculty of Information Technology and Bionics of Pázmány Péter Catholic University. He received his M.D. summa cum laude from Semmelweis University and later earned an M.Sc. in physics/biophysics and a PhD in neuroscience. His work connects the development of high-speed three-dimensional imaging and photostimulation technologies with basic and translational neuroscience. In 2003 he was among the first to develop robust real-time 3D acousto-optic scanner-based laser scanning two-photon microscopes, which have become influential technologies in the field. His research addresses dendritic computation, neuronal network activity, cell-assembly dynamics and visual learning during behaviour. His technological developments enable rapid measurements in large 3D volumes, selective activation of neurons and real-time analysis of complex network processes. At BrainVisionCenter he works on neurophotonic devices and brain interfaces, with particular emphasis on vision restoration and potential future therapies for other central nervous system disorders. His scientific results have appeared in high-impact journals including Science, Nature, Nature Methods, Nature Neuroscience, Neuron, Nature Communications, Cell and eLife. His innovation profile is reinforced by his role as founder and scientific director of Femtonics Ltd., 50 granted international patents and additional patent applications.
Main research areas
- Neuroscience, neurobiology and systems neuroscience
- Two-photon microscopy, 3D acousto-optic laser scanning imaging and neurophotonics
- 3D functional network and dendritic imaging in vivo and in vitro
- Dendritic computation, dendritic integration and cell-assembly activity
- Neuronal population coding, visual learning and network dynamics during behaviour
- Photostimulation and two-photon uncaging technologies
- Brain–machine interfaces, neurophotonic devices and vision restoration
- Development of human diagnostic and therapeutic tools for central nervous system disorders
Current positions and professional profile
- 2022–: Director, BrainVisionCenter Nonprofit Ltd., Budapest.
- 2016–: Group Leader, Laboratory of 3D Functional Network and Dendritic Imaging, Institute of Experimental Medicine, Hungarian Research Network / HUN-REN, Budapest.
- 2010–: Head, Two-photon Imaging Center, Institute of Experimental Medicine.
- 2010–: Head of Laboratory, Faculty of Information Technology and Bionics, Pázmány Péter Catholic University.
- 2005–: Founder and Scientific Director, Femtonics Ltd., Budapest.
Institutional affiliations, memberships and professional collaborations
- Research identifiers and profiles: ORCID: 0000-0003-1427-7003; ResearcherID: C-6306-2015; MTMT publication profile.
- Institutional affiliations: BrainVisionCenter Nonprofit Ltd.; HUN-REN Institute of Experimental Medicine; Two-photon Imaging Center; Faculty of Information Technology and Bionics, Pázmány Péter Catholic University; Femtonics Ltd.
- Hungarian professional collaborations: PPCU; Semmelweis University; Budapest University of Technology and Economics; University of Szeged; National Institute of Clinical Neurosciences; HUN-REN IEM.
- International professional collaborations: Institute of Molecular and Clinical Ophthalmology Basel / IOB; Columbia University; Medical University of Vienna; INSERM Marseille; Max Delbrück Center, Berlin; Max Planck Institute Martinsried; Cold Spring Harbor Laboratory; Ludwig-Maximilians-Universität München; Collège de France; University of Basel; Yale School of Medicine; Medical University of South Carolina; University of Pavia; University of Luxembourg; Radboud University; McGill University; Institute of Experimental Medicine, Prague; Institute of Molecular Biology, Taipei; Uniklinikum Jena; University of Regensburg; Institute of Neuroscience Shanghai, Chinese Academy of Sciences.
- Professional web pages: brainvisioncenter.com; twophotonimaging.eu; femtonics.eu.
Professional roles and engagements
- Supervision of postdoctoral researchers, PhD students and MSc students; supervision record includes 6 postdocs, 6 PhD students and 4 MSc students.
- ERC Consolidator Grant, VISONby3DSTIM (2016–2021): Principal Investigator.
- 3x3D Imaging FP7 project (2013–2016): Principal Investigator and coordinator.
- H2020 projects: beneficiary/contributor roles in AMPLITUDE, VISGEN and NEURAM.
- Leadership and professional participation in international and Hungarian R&D projects, including Swiss-Hungarian, French-Hungarian, FP7, H2020, NKP, NVKP, GINOP, KFI and other research and innovation programmes.
- Invited lecturer and course contributor at international universities, summer schools and conferences, including Oxford, Shanghai ION, IBRO Summer School, MIT, UCL, Stanford University, Columbia University, Boston University, EPFL, FENS Forum, Gordon Research Conference, Photonics West and the International Conference on BioMedical Photonics.
- Development of the BrainVisionCenter research and competence centre in neurophotonic devices, brain interfaces and technologies related to vision restoration.
- Founder and Scientific Director of Femtonics Ltd.; development and translation of neurobiological imaging technologies.
Awards and recognition
- Gábor Dénes Award (2024).
- National Innovation Award (2023).
- Jedlik Ányos Award for outstanding successful inventors’ work (2022).
- Best PhD Supervisor of the Year, Semmelweis University (2020).
- National Innovation Award – “from basic research to market”, NKFIH (2020).
- Ernst & Young Entrepreneur Of The Year – Lifestyle of the Future (2017).
- ERC Consolidator Grant, VISONby3DSTIM (682426) (2016).
- Ernst & Young Entrepreneur Of The Year (2014).
- Magyary Zoltán Professor Scholarship (2013).
- National Innovation Award (2012).
- PNAS publication highlighted as Scientific Highlight of the Year, FENS (2008).
- National Junior Prima Primissima Prize (2007).
Selected publications
- Gonzalez KC; Terada S; Noguchi A; Zakka GN; O'Toole C; Bilbao G; Reynolds L; Jász A; Kertész B; Szadai Z; Shen A; St-Pierre F; Polleux F; Losonczy A; Rózsa B. (2026). Movement-stabilized three-dimensional optical recordings of membrane potential changes and calcium dynamics in hippocampal CA1 dendrites. Neuron.
- Judák L.; Dobos G.; Ócsai K.; Takács I.; Báthory E.; Chiovini B.; Szadai Z.; Maák P.; Szepesi Á.; Roska B.; Szalay G.; Rózsa B. (2024). Competition of cortical clusters during on-demand visual learning in immersive virtual reality. Nature Methods / Research Square preprint.
- Judák L.; Chiovini B.; Juhász G.; Pálfi D.; Mezriczky Z.; Szadai Z.; Katona G.; Szmola B.; Ócsai K.; Martinecz B.; Mihály A.; Dénes Á.; Kerekes B.; Szepesi Á.; Szalay G.; Ulbert I.; Mucsi Z.; Roska B.; Rózsa B. (2022). Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo. Nature Communications.
- Szalay G.; Judák L.; Katona G.; Ócsai K.; Juhász G.; Veress M.; Szadai Z.; Fehér A.; Tompa T.; Chiovini B.; Maák P.; Rózsa B. (2016). Fast 3D Imaging of Spine, Dendritic, and Neuronal Assemblies in Behaving Animals. Neuron.
- Chiovini B.; Turi GF.; Katona G.; Kaszás A.; Pálfi D.; Maák P.; Szalay G.; Szabó MF.; Szabó G.; Szadai Z.; Káli S.; Rózsa B. (2014). Dendritic spikes induce ripples in parvalbumin interneurons during hippocampal sharp waves. Neuron.
- Katona G.; Szalay G.; Maák P.; Kaszás A.; Veress M.; Hillier D.; Chiovini B.; Vizi ES.; Roska B.; Rózsa B. (2012). Fast two-photon in vivo imaging with three-dimensional random-access scanning in large tissue volumes. Nature Methods.
- Szalay G.; Martinecz B.; Lénárt N.; Környei Z.; Orsolits B.; Judák L.; Császár E.; Fekete R.; West BL.; Katona G.; Rózsa B.; Dénes Á. (2016). Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke. Nature Communications.
- Szadai Z.; Pi HJ.; Chevy Q.; Ócsai K.; Albeanu DF.; Chiovini B.; Szalay G.; Katona G.; Kepecs A.; Rózsa B. (2022). Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment. eLife.
- Munz M.; Bharioke A.; Kosche G.; Moreno-Juan V.; Brignall A.; Rodrigues TM.; Graff-Meyer A.; Ulmer T.; Haeuselmann S.; Pavlinic D.; Ledergerber N.; Gross-Scherf B.; Rózsa B.; Krol J.; Picelli S.; Cowan CS.; Roska B. (2023). Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex. Cell.
- Geiller T.; Sadeh S.; Rolotti SV.; Blockus H.; Vancura B.; Negrean A.; Murray AJ.; Rózsa B.; Polleux F.; Clopath C.; Losonczy A. (2022). Local circuit amplification of spatial selectivity in the hippocampus. Nature.
- Wertz A.; Trenholm S.; Yonehara K.; Hillier D.; Raics Z.; Leinweber M.; Szalay G.; Ghanem A.; Keller G.; Rózsa B.; Conzelmann KK.; Roska B. (2015). Single-cell-initiated monosynaptic tracing reveals layer-specific cortical network modules. Science.
Patents and patent applications
Balázs Rózsa holds 50 granted international patents and has additional submitted patent applications. Linkable patent identifiers point to Google Patents pages.
Granted patents
- EP2146234 – Laser scanning microscope (2008.12.31). E. S. Vizi, G. Katona, B. Rózsa
- US2011279893 – Laser scanning microscope (2011.07.27). E. S. Vizi, G. Katona, B. Rózsa
- US20140055852 – Laser scanning microscope (2013.11.15). E. S. Vizi, G. Katona, B. Rózsa
- US2011211254 – Laser scanning microscope for scanning along a 3D trajectory (2011.01.13). B. Rózsa et al.
- EP2307921 – Laser scanning microscope / 3D trajectory scanning family (2009.07.14). B. Rózsa et al.
- US2012044569 – Focusing system comprising acousto-optic deflectors for focusing an electromagnetic beam (2009.12.30). P. Maák, B. Rózsa, G. Katona, E. S. Vizi, M. Veress, A. Csákány, G. Szalay
- CA2748525 – Focusing system comprising acousto-optic deflectors for focusing an electromagnetic beam (2009.12.30). P. Maák, B. Rózsa, G. Katona, E. S. Vizi, M. Veress, A. Csákány, G. Szalay
- CN102334065 – Focusing system comprising acousto-optic deflectors for focusing an electromagnetic beam (2009.12.30). P. Maák, B. Rózsa, G. Katona, E. S. Vizi, M. Veress, A. Csákány, G. Szalay
- EP2399162 – Focusing system comprising acousto-optic deflectors for focusing an electromagnetic beam (2009.12.30). P. Maák, B. Rózsa, G. Katona, E. S. Vizi, M. Veress, A. Csákány, G. Szalay
- EP2187252 – Method and measuring system for scanning multiple regions of interest (2008.12.31). B. Rózsa et al.
- US2011279667 – Method and measuring system for scanning multiple regions of interest (2009.11.17). B. Rózsa et al.
- WO2013098568 – Compensator system and method for compensating angular dispersion (2012.01.05). B. Rózsa et al.
- CA2861716 – Compensator system and method for compensating angular dispersion (2012.01.05). B. Rózsa et al.
- CN104115062 – Compensator system and method for compensating angular dispersion (2012.01.05). B. Rózsa et al.
- EP2798401 – Compensator system and method for compensating angular dispersion (2012.01.05). B. Rózsa et al.
- 6286/DELNP/2014 – Compensator system and method for compensating angular dispersion (2012.01.05). B. Rózsa et al.
- 2014-549539 – Compensator system and method for compensating angular dispersion (2012.01.05). B. Rózsa et al.
- US20150029578A1 – Compensator system and method for compensating angular dispersion (2012.01.05). B. Rózsa et al.
- WO2013102771 – Method for scanning along a continuous scanning trajectory with a scanner system (2012.01.05). B. Rózsa et al.
- CA2861708 – Method for scanning along a continuous scanning trajectory with a scanner system (2012.01.05). B. Rózsa et al.
- CN104115061 – Method for scanning along a continuous scanning trajectory with a scanner system (2012.01.05). B. Rózsa et al.
- EP2800998 – Method for scanning along a continuous scanning trajectory with a scanner system (2012.01.05). B. Rózsa et al.
- 6294/DELNP/2014 – Method for scanning along a continuous scanning trajectory with a scanner system (2012.01.05). B. Rózsa, G. Katona, M. Veress, P. Maák, G. Szalay, A. Kaszás, B. Chiovini, P. Mátyás
- JP2014550762 – Method for scanning along a continuous scanning trajectory with a scanner system (2012.01.05). B. Rózsa, G. Katona, M. Veress, P. Maák, G. Szalay, A. Kaszás, B. Chiovini, P. Mátyás
- 14/368,932 – Scanning trajectory / scanner system patent family application (2012.01.05). B. Rózsa et al.
- WO2013098567 – Methods for measuring a 3-dimensional sample via measuring device comprising a laser scanning microscope and such measuring device (2012.01.05). B. Rózsa et al.
- CA2861721 – Methods for measuring a 3-dimensional sample via measuring device comprising a laser scanning microscope (2012.01.05). B. Rózsa, G. Katona, F. Csikor, P. Maák
- CN104137030 – Methods for measuring a 3-dimensional sample via measuring device comprising a laser scanning microscope (2012.01.05). B. Rózsa, G. Katona, F. Csikor, P. Maák
- EP2798443 – Methods for measuring a 3-dimensional sample via measuring device comprising a laser scanning microscope (2012.01.05). B. Rózsa, G. Katona, F. Csikor, P. Maák
- 6292/DELNP/2014 – Methods for measuring a 3-dimensional sample via measuring device comprising a laser scanning microscope (2012.01.05). B. Rózsa et al.
- JP2014549538 – Methods for measuring a 3-dimensional sample via measuring device comprising a laser scanning microscope (2012.01.05). B. Rózsa et al.
- US20150032414A1 – Methods for measuring a 3-dimensional sample via measuring device comprising a laser scanning microscope (2012.01.05). B. Rózsa et al.
- CN104011020 – Use of photocleavable compounds (2012.10.03). I. B. Rózsa et al.
- HU1200574 – Use of photochemically cleavable compounds (2012.10.03). B. Rózsa et al.
- EP3304184 – Layered structured acousto-optical deflector and method for optical beam deflection with deflector (2016.05.31). B. Rózsa et al.
- ZL201680040531 – Layered structured acousto-optical deflector and method for optical beam deflection (2016.05.31). B. Rózsa et al.
- E051482 – Layered structured acousto-optical deflector and method for optical beam deflection (2016.05.31). B. Rózsa et al.
- JP6866309 – Layered structured acousto-optical deflector and method for optical beam deflection (2016.05.31). B. Rózsa et al.
- US10613414 – Layered structured acousto-optical deflector and method for optical beam deflection (2016.05.31). B. Rózsa et al.
- ZL201780064861.8 – Method for scanning along a 3-dimensional line and for scanning a region of interest by scanning a plurality of 3-dimensional lines (2017.08.31). B. Rózsa et al.
- US11156819 – Method for scanning along a 3-dimensional line and for scanning a region of interest (2017.08.31). B. Rózsa et al.
- EP3507643 – Method for scanning along a 3-dimensional line and for scanning a region of interest (2017.08.31). B. Rózsa et al.
- E064140 – Method for scanning along a 3-dimensional line and for scanning a region of interest (2017.08.31). B. Rózsa et al.
- JP7226316 – Method for scanning along a 3-dimensional line and for scanning a region of interest (2017.08.31). B. Rózsa et al.
- JP7418715 – Method for scanning along a 3-dimensional line and for scanning a region of interest (2017.08.31). B. Rózsa et al.
- IN502445 – Method of scanning an optical beam using an acousto-optic deflector driven by chirped acoustic signals (2019.08.14). B. Rózsa et al.
- JP7444161 – Method of scanning an optical beam using an acousto-optic deflector driven by chirped acoustic signals (2019.08.14). B. Rózsa et al.
- US11927873 – Method of scanning an optical beam using an acousto-optic deflector driven by chirped acoustic signals (2019.08.14). B. Rózsa et al.
- EP3996498 – Virtual reality simulator and method for small laboratory animals (2020.07.09). B. Rózsa et al.
- 231390 – Modular respiratory machine (2023.03.23). B. Rózsa et al.
Submitted patent applications
- P2300026; PCT/HU2023/050092 – Method for scanning an area with a multi-photon laser scanning microscope and such multi-photon laser scanning microscope (2022.12.22). B. Rózsa et al.
- P2200444; PCT/HU2023/050045 – Mobile laser scanning microscope and beam stabilizer for laser scanning microscope (2023.07.06). B. Rózsa et al.
- P2400333 – Microscope system with an optical arm and an optical arm for the examination of freely moving experimental animals (2024.06.25). B. Rózsa et al.
- P2400332 – Movement-stabilized Three-dimensional Two-photon Imaging (2024.06.25). B. Rózsa et al.
- P2300367 – Permanently charged fluorescent derivatization agents developed for glycomic application (2023.10.26). B. Rózsa et al.
- P2300414 – Pyruvate-based fluorescent markers for DNA detection (2023.11.27). B. Rózsa et al.